Why the study?
Elevated adipocyte E2F1 expression in human visceral adipose tissue associates with poor cardiometabolic profile, but whether E2F1 governs a distinct transcriptome contributing to adipose tissue and metabolic dysfunction was unknown.
Population
Age-, sex-, and BMI-matched obese patients, and two independent human cohorts
Comparison
High vs low visceral E2F1 protein expression
Design
Translational study with RNA sequencing and cohort validation
Authors
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E2F1 in visceral adipocytes may mark cardiometabolic risk in obesity; leaves open causal role and therapeutic targeting.
An intra-adipose tissue E2F1-associated TNFSF paracrine loop involving TRAIL and TL1A contributes to adipose tissue dysfunction and metabolic complications in human obesity.
Maixner et al. (2020) studied this question.
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