Why the study?
Does chronic activation of GPR30 with G-1 improve cardiac function and attenuate heart failure in an ovariectomized rat model of isoproterenol-induced heart failure?
Population
Female Sprague-Dawley rats, n=70. Model: bilateral ovariectomy plus isoproterenol to induce heart failure.
Comparison
G-1 120 µg/kg·d via subcutaneous osmotic… vs OVX+ISO receiving no G-1 treatment.
Design
Preclinical, divided into 7 groups
Follow-up
14 days
Authors
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Hypothesis-generating for GPR30 agonism in estrogen-deficient HF; human trials needed before any clinical consideration.
Does chronic activation of GPR30 with G-1 improve cardiac function and attenuate heart failure in an ovariectomized rat model of isoproterenol-induced heart failure?
Chronic activation of the GPR30 receptor with agonist G-1 attenuates isoproterenol-induced heart failure in ovariectomized rats by modulating beta-adrenergic receptor expression.
Kang et al. (2012) studied this question.
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