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September 1, 1996The Journal of Clinical Endocrinology & MetabolismOpen Access

Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction.

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Population

Normal men and men with various disturbances of the hypothalamic-pituitary-testicular axis including…

Comparison

Administration of exogenous levonorgestrel and… vs Baseline values, control/recovery periods, and…

Design

Other

Authors

BAB AnawaltRBRichard A. BebbAMAlvin M. Matsumoto

Discussion

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Overview

May differentiate normal from impaired testicular function; leaves open clinical adoption as a biomarker pending prospective validation.

Structured PICO

P
Population
Normal men and men with various disturbances of the hypothalamic-pituitary-testicular axis including idiopathic hypogonadotropic hypogonadism, infertile men with elevated FSH, Klinefelter's syndrome, and orchidectomized men.
I
Intervention
Administration of exogenous levonorgestrel and testosterone (n=6) or human recombinant FSH (n=10) in subsets of normal men.
C
Comparator
Baseline values, control/recovery periods, and comparisons between normal men and men with testicular dysfunction.
O
Outcome
Serum levels of inhibin A, inhibin B, and pro-alpha-C-related immunoreactive peptides (pro-alpha-C-RI).surrogate

Inhibin B is a unique testicular product responsive to FSH stimulation and likely represents the physiologically important form of inhibin in men.

Cite This Study

Anawalt et al. (1996) studied this question.

synapsesocial.com/papers/6a6f6915febe604dd70855b7https://doi.org/10.1210/jcem.81.9.8784094
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating Immunoreactive Inhibin Levels During the Normal Human Menstrual Cycle*1987 · 300 citations
  2. 2Detection of dimeric inhibin throughout the human menstrual cycle by two‐site enzyme immunoassay1994 · 370 citations
  3. 3Inhibin-B: a likely candidate for the physiologically important form of inhibin in men.1996 · 320 citations
  4. 4Follicle-Stimulating Hormone Is Required for Quantitatively Normal Inhibin Secretion in Men*1988 · 23 citations
  5. 5Inhibin: definition and nomenclature, including related substances1988 · 203 citations