Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 5, 2015PLoS ONEOpen Access

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does Roux-en-Y gastric bypass reduce activation of the NLRP3 inflammasome in metabolically active adipose tissue of obese rats?

Population

16 Sprague-Dawley rats with diet-induced obesity, hyperglycemia, and insulin resistance established by 12…

Comparison

Roux-en-Y gastric bypass (RYGB) surgery vs Sham surgery control

Design

Preclinical, randomized into a control sham-operated, or RYGB surgery group

Follow-up

90 days

Authors

AMAndreea Oana MocanuAMAnny MulyaHHHazel Huang

Discussion

Loading...

Member takes

Overview

RYGB may reduce adipose NLRP3 activation in obese rats; translation to human metabolic outcomes remains untested.

Structured PICO

Does Roux-en-Y gastric bypass reduce activation of the NLRP3 inflammasome in metabolically active adipose tissue of obese rats?

P
Population
16 Sprague-Dawley rats (age 24-25 weeks) with diet-induced obesity, hyperglycemia, and insulin resistance established by 12 weeks of high-fat diet.
I
Intervention
Roux-en-Y gastric bypass (RYGB) surgery
C
Comparator
Sham surgery control
O
Outcome
Expression of NLRP3 inflammasome components (NLRP3, caspase-1, ASC, IL-1β, IL-18, IL-6, MCP-1) in adipose tissue (omental, mesenteric, subcutaneous) and glucose metabolism (OGTT) at 90 days post-surgerysurrogate

Bariatric surgery reverses inflammation in visceral adipose tissue by suppressing NLRP3 inflammasome activation in a rat model of diet-induced obesity.

Cite This Study

Mocanu et al. (2015) studied this question.

synapsesocial.com/papers/6a6f69bff44fa9f079dcd94chttps://doi.org/10.1371/journal.pone.0139764
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss2005 · 1,156 citations
  2. 2Effects of Weight Loss after Bariatric Surgery for Morbid Obesity on Vascular Endothelial Growth Factor-A, Adipocytokines, and Insulin2008 · 127 citations
  3. 3Effect of bariatric surgery on both functional and structural measures of premature atherosclerosis2009 · 68 citations
  4. 4Role of Adipokines in the Obesity???Inflammation Relationship: The Effect of Fat Removal2006 · 85 citations
  5. 5Mutation of the mouse klotho gene leads to a syndrome resembling ageing.1997 · 66,558 citations