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May 13, 2022CureusOpen Access

Peri-Operative Fall in Serum Albumin Levels Correlate Well With Outcomes in Children Undergoing Emergency Abdominal Surgery: A Prospective Study From a Resource-Limited Setting

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Why the study?

Data were limited on using peri-operative fall in serum albumin levels as an outcome predictor in children undergoing emergency abdominal surgeries.

Does a peri-operative fall in serum albumin level ≥ 0.5 g/dl predict increased complications and longer hospital stay in children undergoing emergent abdominal surgery?

Comparison

Fall in serum albumin level < 0.5 vs >= 0.5 gm/dl

Design

Prospective study

Authors

RRRafey Abdul RahmanAdesh UniversityMAMuniba AlimAdesh UniversitySASachit AnandAll India Institute of Medical Sciences

Discussion

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Implication

Greater peri-operative albumin decline may flag higher-risk children after emergency abdominal surgery; leaves open incremental prognostic value beyond standard markers.

Structured PICO

Does a peri-operative fall in serum albumin level ≥ 0.5 g/dl predict increased complications and longer hospital stay in children undergoing emergent abdominal surgery?

P
Population
56 children aged 2-15 years (mean age 8.57, 60.7% male) undergoing emergent abdominal surgeries at a tertiary care center in rural India. Exclusions: polytrauma, malignancy, chronic liver diseases, and hematological diseases.
I
Intervention
Peri-operative fall in serum albumin level (∆A) ≥ 0.5 g/dl (Group 2, n=18)
C
Comparator
Peri-operative fall in serum albumin level (∆A) < 0.5 g/dl (Group 1, n=38)
O
Outcome
Postoperative complications (categorized by Dindo-Clavien system) and length of hospital stayhard clinical

A peri-operative fall in serum albumin ≥ 0.5 g/dl is a useful, inexpensive early marker of surgical stress that correlates with increased postoperative complications and longer hospital stays in children undergoing emergency abdominal surgery.

Limitations

  • Small sample size
  • Short recruitment time
  • Heterogeneous cohort preventing identification of a standard cut-off value
  • Use of one-time preoperative and postoperative serum albumin values with risk of laboratory error

Cite This Study

Rahman et al. (2022) studied this question.

synapsesocial.com/papers/6a6f69cb5d37378ac1dc78b5https://doi.org/10.7759/cureus.24960
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Postoperative Albumin Drop Is a Marker for Surgical Stress and a Predictor for Clinical Outcome: A Pilot Study2016 · 192 citations
  2. 2Perioperative serum albumin and its influence on clinical outcomes in neonates and infants undergoing cardiac surgery with cardiopulmonary bypass: a multi-centre retrospective study2019 · 19 citations
  3. 3Preoperative Serum Albumin Level as a Predictor of Operative Mortality and Morbidity1999 · 1,009 citations
  4. 4The Clavien-Dindo Classification of Surgical Complications2009 · 11,642 citations
  5. 5Interpretation of C-Reactive Protein Concentrations in Critically Ill Patients2013 · 166 citations