Why the study?
Hypoalbuminemia is linked to morbidity and mortality in critically ill children, but normative values and the impact of perioperative albumin levels in neonates and infants with congenital heart disease were unclear.
Population
203 neonates and infants undergoing cardiac surgery with cardiopulmonary bypass
Comparison
Perioperative serum albumin levels and hypoalbuminemia vs normal albumin levels
Design
Multi-centre retrospective study
Key result
Pre-operative low serum albumin level was independently associated with increased odds of post-operative hypoalbuminemia (OR 3.67; 95% CI 1.01-13.29) and prolonged length of hospital stay.
Authors
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Lower perioperative albumin levels were associated with prolonged ventilation and stay after infant CHD surgery; hypothesis-generating for supplementation trials.
Cohort (n=203)
Yes
Odds Ratio: 3.67 (95% CI 1.01–13.29)
Lower perioperative serum albumin levels in neonates and infants undergoing cardiac surgery with cardiopulmonary bypass are associated with increased post-operative morbidity, including prolonged mechanical ventilation and hospital stay.
Henry et al. (2019) conducted a cohort in congenital heart disease (n=203). Pre-operative low serum albumin level vs. Normal serum albumin level was evaluated on post-operative hypoalbuminemia (OR 3.67, 95% CI 1.01-13.29). Pre-operative low serum albumin level was independently associated with increased odds of post-operative hypoalbuminemia (OR 3.67; 95% CI 1.01-13.29) and prolonged length of hospital stay.
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