Retrospective cohort study reveals albumin levels influence postoperative outcomes in pediatric congenital heart surgery.
Key Points
This study aims to investigate the relationship between preoperative serum albumin levels and early postoperative morbidity in pediatric patients undergoing congenital heart surgery.
Retrospective cohort study of 1033 pediatric patients with congenital heart disease who underwent cardiopulmonary bypass surgery.
Multivariable logistic regression and restricted cubic spline analyses were utilized to evaluate associations between serum albumin levels and postoperative outcomes.
Adverse outcomes included mortality, reintubation, prolonged mechanical ventilation, and extended hospitalization.
The second quartile of serum albumin was associated with an odds ratio (OR) of 0.542 (95% CI: 0.328–0.889) for adverse outcomes compared to the lowest quartile.
The fourth quartile showed an OR of 0.466 (95% CI: 0.268–0.795) for reduced risks of postoperative events.
Incremental increases in albumin levels up to 40.65 g/L were significantly associated with reduced adverse outcomes (OR = 0.864; 95% CI: 0.755–0.983; P = 0.030).