February 7, 2003The Journal of PhysiologyOpen Access

State-dependent regulation of cortical blood flow and respiration in hamsters: response to hypercapnia during arousal from hibernation

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Population

Syrian hamsters chronically implanted with a cortical thermocouple and an optical fibre over the…

Comparison

Exposure to hypercapnic and hyperoxic gases… vs Different physiological states

Design

Preclinical

Authors

POPeter G. OsborneCorteva (United States)MHMasaaki HashimotoKyorin University

Discussion

Member takes

Implication

State-dependent hypercapnic responses in hibernating hamsters leave open analogous protective mechanisms in human arousal; translational studies needed before clinical relevance.

Structured PICO

Population

Syrian hamsters chronically implanted with a cortical thermocouple and an optical fibre over the contralateral cortex, and acutely implanted with thermocouples in the rectal, cheek pouch and interscapular brown adipose tissue (BAT)

Intervention

Exposure to hypercapnic and hyperoxic gases during arousal from hibernation and at cenothermia

Comparator

Different physiological states (arousal from hibernation vs. cenothermia)

Outcome

Regional cortical blood flow (rCBF), respiratory rate (RR), and heart rate (HR)surrogate

In Syrian hamsters, the regulation of cortical blood flow, heart rate, and respiratory rate shows state-dependent responses to hypercapnia, suggesting endogenous mechanisms to manage massive blood flow increases during arousal from hibernation.

Cite This Study

Osborne et al. (2003) studied this question.

synapsesocial.com/papers/6a6f69cef44fa9f079dcd984 https://doi.org/10.1113/jphysiol.2002.033571

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Implication

State-dependent hypercapnic responses in hibernating hamsters leave open analogous protective mechanisms in human arousal; translational studies needed before clinical relevance.