Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 20, 2022International Journal of Molecular SciencesOpen Access

Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4

View Full Paper
Ask AI
Bookmark
Share

Why the study?

NPR1 modulates vascular endothelial homeostasis, and interactions between monocytes and endothelial cells can initiate endothelial dysfunction, an early hallmark of atherosclerosis.

Population

Aorta of Npr1 knockout (Npr1+/-) mice, HUVECs, THP-1 monocytes, and an atherosclerosis mouse model

Comparison

NPR1 deficiency or knockdown vs control, and NPR1 overexpression vs TNF-alpha treatment

Design

Preclinical laboratory and animal study

Authors

HLHongfei LiuNanchang UniversityJLJiankun LiuMitsubishi Heavy Industries (Germany)CLChangkun LongChangzhou University

Discussion

Loading...

Member takes

Implication

NPR1 loss alters endothelial adhesion genes in mice; leaves open its role in human atherosclerosis.

Structured PICO

P
Population
Npr1 knockout (Npr1+/-) mice, human umbilical vein endothelial cells (HUVECs), THP-1 monocytes, and an atherosclerosis mouse model
I
Intervention
NPR1 knockdown, NPR1 overexpression, and ITGB4 deficiency
C
Comparator
Wild-type mice and control cells
O
Outcome
Vascular endothelial cell adhesion (ICAM-1 expression and monocyte adhesion)surrogate

NPR1 deficiency promotes vascular endothelial cell adhesion and potential atherosclerosis development through the induction of integrin beta 4 (ITGB4).

Cite This Study

Liu et al. (2022) studied this question.

synapsesocial.com/papers/6a6f69cf2163a0a01bc3b5dehttps://doi.org/10.3390/ijms232012627
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Atherosclerosis and Smooth Muscle Cell Hypertrophy in Natriuretic Peptide Receptor A −/− Apolipoprotein E −/− Mice2003 · 36 citations
  2. 2Inflammation: A Link Between Hypertension and Atherosclerosis2009 · 37 citations
  3. 3EGF-induced MAPK Signaling Inhibits Hemidesmosome Formation through Phosphorylation of the Integrin β42010 · 71 citations
  4. 4Role of Endothelial Dysfunction in Atherosclerosis2004 · 2,524 citations
  5. 5Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation2016 · 72 citations