Why the study?
Does the lack of natriuretic peptide receptor A increase atherosclerosis and cardiac hypertrophy in apolipoprotein E-deficient mice?
Population
Mice lacking natriuretic peptide receptor A crossbred with atherosclerosis-prone mice lacking apolipoprotein E
Comparison
Genetic deletion of both Npr1 and Apoe vs Npr1+/+Apoe-/- mice and Npr1-/-Apoe+/+ mice
Design
Preclinical
Authors
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Animal data on NPR1 in atherosclerosis are hypothesis-generating; leaves open relevance to human disease or therapy.
Does the lack of natriuretic peptide receptor A increase atherosclerosis and cardiac hypertrophy in apolipoprotein E-deficient mice?
Genetic deletion of natriuretic peptide receptor A in apolipoprotein E-deficient mice synergistically increases atherosclerosis, blood pressure, and cardiac hypertrophy, suggesting NPR1 is an atherosclerosis susceptibility locus.
Alexander et al. (2003) studied this question.
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