Population
Npr1-/- mice with cardiac hypertrophy and fibrosis, and wild-type (WT) mice
Comparison
Disruption of the Npr1 signaling pathway vs Wild-type (WT) mice
Design
Preclinical
Authors
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Ventricular ANP/BNP upregulation in Npr1-/- mice may mark local hypertrophy over systemic BP; hypothesis-generating for sex differences and human relevance.
Cardiac ventricular expression of ANP and BNP is more closely associated with local hypertrophy and fibrosis than systemic blood pressure or circulating ANP levels in Npr1-/- mice.
Ellmers et al. (2002) studied this question.
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