Population
Mice with targeted disruption of BNP (BNP-/- mice)
Comparison
Targeted disruption of BNP gene with or without… vs Wild-type mice (implied)
Design
Preclinical
Authors
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BNP deficiency promotes ventricular fibrosis under pressure overload in mice; leaves open whether BNP augmentation prevents fibrosis in human heart disease.
BNP acts locally as a cardiocyte-derived antifibrotic factor, and its absence leads to ventricular fibrosis, especially under pressure overload.
Ogawa et al. (2001) studied this question.
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