Enhanced atherosclerosis and kidney dysfunction in eNOS–/–Apoe–/– mice are ameliorated by enalapril treatment
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Why the study?
Does enalapril treatment ameliorate enhanced atherosclerosis and kidney dysfunction in eNOS-/-Apoe-/- mice?
Population
Mice deficient in both apolipoprotein E and endothelial nitric oxide synthase, referred to as nnee mice
Comparison
Enalapril treatment vs Untreated nnee mice, normotensive…
Design
Preclinical
Authors
Discussion
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Implication
Enalapril may mitigate eNOS-driven damage in mouse models; leaves open clinical translation to human atherosclerosis and kidney disease.
Structured PICO
Does enalapril treatment ameliorate enhanced atherosclerosis and kidney dysfunction in eNOS-/-Apoe-/- mice?
P
Population
Mice deficient in both apolipoprotein E (Apoe-/-) and endothelial nitric oxide synthase (eNOS-/-), referred to as nnee mice
I
Intervention
Enalapril treatment
C
Comparator
Untreated nnee mice, normotensive atherosclerotic mice (NNee), and mice lacking inducible NOS
O
Outcome
Blood pressure, atherosclerotic lesion size, and kidney dysfunction (plasma creatinine, kidney weight/body weight ratio, glomerular lipid deposition and calcification)surrogate
Enalapril treatment ameliorates enhanced atherosclerosis and kidney dysfunction driven by eNOS deficiency and hypertension in ApoE-/- mice.
Cite This Study
Knowles et al. (2000) studied this question.
Topics
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