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February 18, 2014Acta DiabetologicaOpen Access

Less but better: cardioprotective lipid profile of patients with GCK-MODY despite lower HDL cholesterol level

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Population

79 patients including 21 with GCK-MODY, 16 with HNF1A-MODY, 22 with type 1 diabetes, and 15 healthy…

Design

Cross-sectional

Authors

WFWojciech FendlerMRManfredi RizzoMBMaciej Borowiec

Discussion

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Overview

May indicate lower CV risk in GCK-MODY despite lower total HDL-C; hypothesis-generating and requires prospective validation before clinical adoption.

Structured PICO

P
Population
79 patients including 21 with GCK-MODY, 16 with HNF1A-MODY, 22 with type 1 diabetes (T1DM), and 15 healthy controls. GCK-MODY group median age 25.05 years, 12 male / 9 female.
O
Outcome
Composition of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subpopulations measured by non-denaturing, linear polyacrylamide gel electrophoresis (LipoPrint system)surrogate

Patients with GCK-MODY exhibit a cardioprotective HDL subpopulation profile characterized by high large HDL and low intermediate/small HDL, despite having lower total HDL cholesterol levels.

Limitations

  • Small sample size
  • Lack of C-reactive protein (CRP) and apolipoprotein M (ApoM) evaluation
  • Inability to measure blood glucose levels at the time of blood withdrawal
  • Lack of uniform cardiovascular risk scores (e.g., coronary artery calcification)
  • Potential bias from different duration of sample storage

Cite This Study

Fendler et al. (2014) studied this question.

synapsesocial.com/papers/6a6f6cdc22b3175134db4382https://doi.org/10.1007/s00592-014-0567-1
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  4. 4Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness2013 · 16 citations
  5. 5Genotype-Phenotype Discrepancies in Family Members With a Novel Glucokinase Mutation: Insights Into GCK-MODY and Its Interplay With Insulin Resistance2025