Answers are grounded in this paper and cite their sources.
Conformational flexibility of L-iduronic acid is a key feature of this typical component of heparin. Three pentasaccharides have now been synthesized, which are analogues of the active site of heparin and in which the single L-iduronic acid is conformationally locked in either the 1C4, 4C1, or 2S0 form. Only the 2S0 variant 1 was able to fully activate antithrombin inhibition of the blood coagulation factor Xa.
No takes yet. Share an insight, caveat, or question.
Das et al. (2001) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: