Develops an improved mathematical method for correcting distorted venoarterial indicator dilution curves.
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May improve accuracy of cardiac output estimates from distorted curves; leaves open prospective clinical validation.
Venoarterial indicator dilution curves are distorted by non-ideal injection and by the monitoring system. An improved method of correcting these curves is developed assuming that a linear model of perfect mixers in series can be fitted to the physiologic system response as well as to the subsystem responses.
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Nassí et al. (1979) studied this question.
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