What question did this study set out to answer?

This review aims to clarify the anatomy and role of the nucleus basalis of Meynert (nbM) in Alzheimer's and Parkinson's diseases.

January 29, 2015Acta NeuropathologicaOpen Access

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease

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Review highlights differential neuronal loss patterns in Alzheimer's and Parkinson's diseases, indicating implications for cognitive decline.

This review aims to clarify the anatomy and role of the nucleus basalis of Meynert (nbM) in Alzheimer's and Parkinson's diseases.
Comprehensive literature review and analysis of the role of nbM in dementia.
Hypothesized differing patterns of neuronal loss in nbM between Alzheimer's and Parkinson's disease.
Standardization of nbM sampling for neuropathological studies was highlighted.
Substantial neuronal loss in the nbM correlates with cognitive decline in Alzheimer's disease.
Evidence suggests a specific caudorostral pattern of neuronal loss within the nbM in Alzheimer's brains.
Findings in Parkinson's disease are more ambiguous due to fewer studies, indicating the need for further research.

Liu et al. (2015) studied this question.

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Review highlights differential neuronal loss patterns in Alzheimer's and Parkinson's diseases, indicating implications for cognitive decline.