Why the study?
Does thoracic radiotherapy cause capillary injury preceding myocardial fibrosis in young rabbits?
Population
Young rabbits
Design
Preclinical
Follow-up
two to seventy days
Authors
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Implicates early endothelial injury in radiation fibrosis in young rabbits; hypothesis-generating for human cardiotoxicity mechanisms.
Does thoracic radiotherapy cause capillary injury preceding myocardial fibrosis in young rabbits?
Radiation-induced myocardial fibrosis appears to be driven by early capillary and endothelial injury rather than direct myocyte damage.
Fajardo et al. (1971) studied this question.
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