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February 1, 1968Proceedings of the National Academy of SciencesOpen Access

A two-step mechanism for the interaction of estradiol with rat uterus.

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Authors

EJE. V. JensenBar-Ilan UniversityTSTetsuro SuzukiHamamatsu UniversityTKT. KawashimaAsahikawa Medical College Hospital

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Implication

Laboratory investigation reveals a two-step interaction mechanism for estradiol in rat uterine tissue, indicating sequential receptor activation.

Key Points

  • To elucidate the biochemical pathway and binding mechanism governing how estradiol interacts with target uterine cells.
  • Biochemical binding assays evaluating estradiol uptake and retention in rat uterine tissue.
  • Analysis of intracellular hormone distribution across cytoplasmic and nuclear cellular fractions.
  • Estradiol binds initially to a specific cytoplasmic receptor before the complex undergoes transformation.
  • The transformed hormone-receptor complex relocates into the nucleus to initiate biological responses.

Cite This Study

Jensen et al. (1968) studied this question.

synapsesocial.com/papers/6a6f715dac440176ef281ddehttps://doi.org/10.1073/pnas.59.2.632
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