March 29, 2011PLoS ONEOpen Access

Human Rhinovirus Infections in Rural Thailand: Epidemiological Evidence for Rhinovirus as Both Pathogen and Bystander

View Full Paper

Ask AI

Bookmark

Population

3,790 participants in Sa Kaeo province, Thailand, including 1,941 hospitalized patients with acute lower…

Design

Case-control, Laboratory personnel were blinded to patient status.

Authors

AFAlicia M. FryIntermountain Healthcare XLXiaoyan LuUniversity College Dublin SOSonja J. OlsenNational Influenza Center

Discussion

Member takes

Implication

HRV may represent a true pathogen in hospitalized LRTI; leaves open prospective validation before changing testing or management.

Structured PICO

Population

3,790 participants in Sa Kaeo province, Thailand, including 1,941 hospitalized patients with acute lower respiratory illness, 1,569 outpatients with influenza-like illness, and 280 asymptomatic outpatient controls.

Outcome

Detection of human rhinovirus (HRV) by RT-PCR and its epidemiological association with hospitalized lower respiratory tract illness.

Human rhinovirus is significantly associated with hospitalized lower respiratory tract illness in both children and adults in rural Thailand, highlighting its role as a true pathogen rather than just a bystander virus.

Limitations

Did not enroll eligible patients without a chest radiograph ordered within 48 hours of admission
Young children and ICU patients were less likely to enroll
Limited testing for bacterial co-detections
Outpatient sample was a convenience sample
Did not ask controls about illness more than 3 days prior or record presence of rhinorrhea

Cite This Study

Fry et al. (2011) studied this question.

synapsesocial.com/papers/6a6f723684cc45bb7bdf9fd0 https://doi.org/10.1371/journal.pone.0017780

View Full Paper

Ask AI

Bookmark

Human Rhinovirus Infections in Rural Thailand: Epidemiological Evidence for Rhinovirus as Both Pathogen and Bystander

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Human Rhinovirus Infections in Rural Thailand: Epidemiological Evidence for Rhinovirus as Both Pathogen and Bystander

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider