What question did this study set out to answer?

To determine whether liver allograft preservation using histidine-tryptophan-ketoglutarate (HTK) compared with University of Wisconsin (UW) solution affects overall and early graft survival.

December 4, 2008American Journal of TransplantationOpen Access

Histidine–Tryptophan–Ketoglutarate (HTK) Is Associated with Reduced Graft Survival in Deceased Donor Livers, Especially Those Donated After Cardiac Death

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Authors

ZSZoe A. StewartUniversity Hospitals of Cleveland ACAndrew M. CameronJohns Hopkins University ASA.L. SingerWinnMed

Discussion

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Implication

Registry analysis demonstrates reduced graft survival with HTK solution in deceased donor liver transplant recipients, indicating a need to reexamine HTK preservation practices.

Key Points

To determine whether liver allograft preservation using histidine-tryptophan-ketoglutarate (HTK) compared with University of Wisconsin (UW) solution affects overall and early graft survival.
Analyzed the UNOS database of deceased donor liver transplants performed from July 2004 through February 2008.
Compared outcomes between allografts preserved with HTK (n = 4,755) versus UW solution (n = 12,673), adjusting for donor, recipient, and graft variables.
Adjusted multivariable analysis associated HTK preservation with an increased overall risk of graft loss (HR 1.14, p = 0.002), with elevated risks in DCD allografts (HR 1.44, P = 0.025) and cold ischemia time >8 h (HR 1.16, P = 0.009).
HTK was associated with higher odds of early (<30 days) graft loss (OR 1.20, p = 0.012), especially for cold ischemia time >8 h (OR 1.31, p = 0.007), DCD allografts (OR 1.63, p = 0.09), and donors >70 years (OR 1.67, p = 0.081).

Cite This Study

Stewart et al. (2008) studied this question.

synapsesocial.com/papers/6a6f73a031a3df824327d328 https://doi.org/10.1111/j.1600-6143.2008.02478.x

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Implication

Registry analysis demonstrates reduced graft survival with HTK solution in deceased donor liver transplant recipients, indicating a need to reexamine HTK preservation practices.

Histidine–Tryptophan–Ketoglutarate (HTK) Is Associated with Reduced Graft Survival in Deceased Donor Livers, Especially Those Donated After Cardiac Death

Discussion

Member takes

Implication

Key Points

Cite This Study

Histidine–Tryptophan–Ketoglutarate (HTK) Is Associated with Reduced Graft Survival in Deceased Donor Livers, Especially Those Donated After Cardiac Death

Discussion

Member takes

Implication

Key Points

Cite This Study

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