April 9, 2014Critical Care Medicine

A Multiscale Entropy-Based Tool for Scoring Severity of Systemic Inflammation*

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Why the study?

Does multiscale entropy analysis of beat-to-beat dynamics predict survival outcome in mouse models of inflammatory shock?

Population

Blood pressure transmitter-implanted female C57BL/6J mice (n=25)

Comparison

Analysis of beat-to-beat interval variability… vs Linear indices of variability, unifractal…

Design

Preclinical

Authors

BVBenjamin VandendriesscheCase Western Reserve University HPHarlinde PeperstraeteGhent University Hospital ERElke RoggeInstituut voor Landbouw en Visserijonderzoek

Discussion

Member takes

Implication

May support early prognostication in murine inflammatory shock; hypothesis-generating and leaves open human translation.

Structured PICO

Does multiscale entropy analysis of beat-to-beat dynamics predict survival outcome in mouse models of inflammatory shock?

Population

Blood pressure transmitter-implanted female C57BL/6J mice (n=25)

Intervention

Analysis of beat-to-beat interval variability using multiscale entropy after IV administration of tumor necrosis factor (n=11) or lipopolysaccharide (n=14)

Comparator

Linear indices of variability, unifractal dynamics, and absolute heart rate or blood pressure

Outcome

Prediction of survival outcomesurrogate

Multiscale entropy analysis of beat-to-beat dynamics can predict survival early in mouse models of systemic inflammation.

Cite This Study

Vandendriessche et al. (2014) studied this question.

synapsesocial.com/papers/6a6f746a35aa2c282ce0d182 https://doi.org/10.1097/ccm.0000000000000299

View Full Paper

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A Multiscale Entropy-Based Tool for Scoring Severity of Systemic Inflammation*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Multiscale Entropy-Based Tool for Scoring Severity of Systemic Inflammation*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider