Vitamin D and Ovarian Cancer

Ovarian cancer causes more deaths than any other cancer of the female reproductive system.The vitamin D receptor (VDR) is weakly to moderately expressed in normal ovarian cell, but is more strongly expressed in ovarian cancer line and tumor tissue.In vitro studies have reported that vitamin D administration inhibits cell growth and induces apoptosis in a dose dependent manner in both animal and human ovarian cancer cell lines.With available literature in the background, there is an urgent need to conduct a large case control trial to evaluate the association of vitamin D receptor gene polymorphism Fok1 with the risk of epithelial ovarian cancer.Also, we need to evaluate the levels of serum vitamin D in epithelial ovarian cancer patients.