Population
Mouse bone marrow-derived mast cells (including those derived from C3H/HeJ mice)
Comparison
LPS stimulation, IgE cross-linking, and… vs Unstimulated cells or cells without inhibitors
Design
Preclinical
Authors
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May link bacterial LPS to mast cell-driven Th2 responses in asthma; hypothesis-generating, with no clinical implications yet.
LPS-mediated production of Th2 cytokines in mast cells is dependent on TLR4 and regulated by specific MAP kinases, providing insight into how bacterial infections may exacerbate allergic asthma.
Christopher Wren (2002) studied this question.
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