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August 17, 2001The FASEB JournalOpen Access

Preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo

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Population

Rat olfactory sensory neurons, rodent CNS neurons in vitro and in vivo, and organotypic slices of human…

Design

Preclinical

Authors

CSClaire SoudaisInsermCLCorinne Laplace‐BuilhéCentre National de la Recherche ScientifiqueKKKarima KissaInserm

Discussion

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Implication

CAV-2 merits further preclinical optimization for CNS gene delivery; leaves open safety, efficacy, and human translation.

Structured PICO

P
Population
Rat olfactory sensory neurons, rodent CNS neurons in vitro and in vivo, and organotypic slices of human cortical brain
I
Intervention
Canine adenovirus vector (CAV-2)
O
Outcome
Neuronal transduction efficacy and retrograde axonal transportsurrogate

CAV-2 vectors demonstrate preferential neuronal transduction and efficient retrograde transport, highlighting their potential for targeted gene delivery in the central nervous system.

Cite This Study

Soudais et al. (2001) studied this question.

synapsesocial.com/papers/6a6f778b439bab0cabc2cd72https://doi.org/10.1096/fj.01-0321fje
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