Restoring Sinus Rhythm Improves Baroreflex Function in Patients With Persistent Atrial Fibrillation
Why the study?
Does restoring sinus rhythm improve baroreflex function in patients with persistent atrial fibrillation?
Population
24 patients with persistent atrial fibrillation referred for cardioversion, and a control group with no…
Comparison
Cardioversion to restore sinus rhythm vs Control group with no history of atrial…
Design
Cohort
Follow-up
30 days
Authors
Discussion
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Member takes
Implication
Restoring sinus rhythm may improve baroreflex function in persistent AF; leaves open clinical impact in prospective trials.
Structured PICO
Does restoring sinus rhythm improve baroreflex function in patients with persistent atrial fibrillation?
P
Population
24 patients with persistent atrial fibrillation referred for cardioversion, and a control group with no history of atrial fibrillation matched for age and left ventricular ejection fraction.
I
Intervention
Cardioversion to restore sinus rhythm
C
Comparator
Control group with no history of atrial fibrillation (matched for age and LVEF), and within-group comparison (baseline vs 30 days post-cardioversion)
O
Outcome
Baroreflex gain (BRG) measured on the day of cardioversion (Day 1) and at 30 days post-cardioversion (Day 30)surrogate
Restoration of sinus rhythm in patients with persistent atrial fibrillation significantly improves baroreflex function, suggesting the arrhythmia itself contributes to baroreflex impairment.
Cite This Study
Field et al. (2016) studied this question.