Why the study?
Does N-acetylcysteine prevent congenital heart defects in the offspring of mice with pregestational diabetes?
Population
Female mice treated with streptozotocin (STZ) to induce pregestational diabetes and their offspring
Comparison
N-acetylcysteine in drinking water from E0.5 to… vs Diabetic mice without NAC treatment
Design
Preclinical
Follow-up
From E0.5 to the end of gestation or harvesting of the…
Authors
Loading...
Supports NAC investigation in diabetic pregnancy models; leaves open human CHD prevention.
Does N-acetylcysteine prevent congenital heart defects in the offspring of mice with pregestational diabetes?
In a mouse model, maternal treatment with N-acetylcysteine prevents the development of congenital heart defects in the offspring of pregestational diabetic mothers by reducing reactive oxygen species.
Moazzen et al. (2014) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: