Why the study?
Does baroreflex gain differ between patients with inappropriate sinus tachycardia and healthy volunteers at rest and during orthostatic stress?
Population
8 patients with clinical criteria of inappropriate sinus tachycardia (IST) and 9 healthy volunteers (CON)
Comparison
Orthostatic stress at 60 degrees vs Healthy volunteers
Design
Case-control
Authors
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Reduced baroreflex gain may underlie IST; hypothesis-generating for autonomic mechanisms and targeted therapies.
Does baroreflex gain differ between patients with inappropriate sinus tachycardia and healthy volunteers at rest and during orthostatic stress?
Patients with inappropriate sinus tachycardia have markedly impaired baroreflex gain at rest and during orthostatic stress, which may contribute to their elevated heart rates.
León et al. (2005) studied this question.
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