What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Healthy (n=117). Intervention: Sympathovagal balance. Primary outcome: Short-term blood pressure variability (BPV).

What question did this study set out to answer?

The study aimed to explore the physiological correlates of short-term blood pressure variability and its connections to neural and hormonal systems in healthy individuals.

April 1, 1999AJP Heart and Circulatory Physiology

Sympathovagal balance is major determinant of short-term blood pressure variability in healthy subjects

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Key result

Cardiac sympathovagal balance is the major determinant of short-term blood pressure variability in healthy subjects, correlating positively with total power and low-frequency BPV components.

Population

117 healthy, normal-weight, nonsmoking male and female subjects aged 23-77 yr

Design

Cross-sectional

Authors

TLTomi LaitinenTulane University JHJuha HartikainenElectrophysiology LNLeo Niskanen358 (Finland)

Discussion

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Implication

Hypothesis-generating in healthy subjects; prospective studies needed before clinical relevance in disease.

Key Points

The study aimed to explore the physiological correlates of short-term blood pressure variability and its connections to neural and hormonal systems in healthy individuals.
117 healthy, normal-weight, nonsmoking individuals aged 23-77 were analyzed.
Blood pressure variability and heart rate variability were assessed using spectral analysis during controlled breathing.
Baroreflex sensitivity and vasoactive hormone levels were measured to evaluate their relationship with blood pressure variability.
A positive correlation was found between sympathovagal balance and overall blood pressure variability (total power) with specific frequency components (very low and low frequencies).
Baroreflex sensitivity showed an inverse correlation with blood pressure variability, indicating less variability with higher sensitivity.
Factors like age, gender, body mass index, and systolic blood pressure also influenced blood pressure variability, while vasoactive hormones did not significantly correlate.

Study Design

Type

Cross-Sectional (n=117)

Structured PICO

Population

117 healthy, normal-weight, nonsmoking adults aged 23-77 years.

Outcome

Associations between blood pressure variability (BPV) and neural and hormonal regulatory systems at restsurrogate

Sympathovagal balance, along with age, gender, BMI, blood pressure, and baroreflex sensitivity, is a major determinant of short-term blood pressure variability in healthy subjects.

Cite This Study

Laitinen et al. (1999) conducted a cross-sectional in Healthy (n=117). Sympathovagal balance was evaluated on Short-term blood pressure variability (BPV). Cardiac sympathovagal balance is the major determinant of short-term blood pressure variability in healthy subjects, correlating positively with total power and low-frequency BPV components.

synapsesocial.com/papers/6a22563b71fe5424977c95cf https://doi.org/10.1152/ajpheart.1999.276.4.h1245

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Sympathovagal balance is major determinant of short-term blood pressure variability in healthy subjects

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Sympathovagal balance is major determinant of short-term blood pressure variability in healthy subjects

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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Also Consider