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February 15, 1999Blood

A Reduced Sensitivity for Activated Protein C in the Absence of Factor V Leiden Increases the Risk of Venous Thrombosis

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Authors

MVMarieke C. VisserSt. Antonius Ziekenhuis
Frits R. Rosendaal
Frits R. RosendaalVascular MedicineRBRogier M. BertinaLeiden University Medical Center

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Visser et al. (1999) studied this question.

synapsesocial.com/papers/6a6f78918031ec7bb1dbc3dahttps://doi.org/10.1182/blood.v93.4.1271
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factor V Cambridge: A New Mutation (Arg306→Thr) Associated With Resistance to Activated Protein C1998 · 293 citations
  2. 2The influence of factor VIII on measurement of activated protein C resistance1996 · 69 citations
  3. 3Spectrophotometric Assays of Prothrombin in Plasma of Patients Using Oral Anticoagulants1979 · 42 citations
  4. 4Mutation at either Arg336 or Arg562 in Factor VIII Is Insufficient for Complete Resistance to Activated Protein C (APC)-mediated Inactivation: Implications for the APC Resistance Test1998 · 40 citations
  5. 5Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.1993 · 1,986 citations