What question did this study set out to answer?

To document long-term changes in etiology, bacteriology, diagnostic methods, interventions, and survival among patients treated for pyogenic hepatic abscesses across four decades.

May 1, 1996Annals of SurgeryOpen Access

Pyogenic Hepatic Abscess

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To document long-term changes in etiology, bacteriology, diagnostic methods, interventions, and survival among patients treated for pyogenic hepatic abscesses across four decades.
Retrospective medical record review of 233 patients with pyogenic liver abscesses treated over a 42-year interval.
Comparative analysis between an early cohort treated from 1952 to 1972 (n = 80) and a recent cohort treated from 1973 to 1993 (n = 153).
In the modern era (1973–1993), abscess incidence increased from 13 to 20 per 100,000 admissions (p < 0.01), with higher rates of underlying malignancy (52% vs. 28%, p < 0.01), polymicrobial or fungal infections (26% vs. 1%, p < 0.05), and percutaneous drainage use (45% vs. 0%, p < 0.05).
Overall mortality fell significantly from 65% in 1952–1972 to 31% in 1973–1993 (p < 0.01), with the most pronounced reductions occurring in patients with multiple abscesses (88% vs. 44%, p < 0.05) and biliary etiology (90% vs. 38%, p < 0.05).
Patients with mixed bacterial and fungal abscesses experienced higher mortality (50%, p < 0.02), whereas open surgical drainage showed non-significantly lower mortality than percutaneous drainage (14% vs. 26%, p = 0.19) in the recent cohort.

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Implication

Retrospective cohort study reveals halved mortality despite rising malignancy rates in pyogenic hepatic abscess, highlighting advances in diagnostic imaging and drainage techniques.

Cite This Study

Huang et al. (1996) studied this question.

synapsesocial.com/papers/6a6f7a0626a7f98052dc227f https://doi.org/10.1097/00000658-199605000-00016

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Implication

Retrospective cohort study reveals halved mortality despite rising malignancy rates in pyogenic hepatic abscess, highlighting advances in diagnostic imaging and drainage techniques.

Pyogenic Hepatic Abscess

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Pyogenic Hepatic Abscess

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Implication

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