Why the study?
Decades of RAAS research can be applied to better understand COVID-19 pathophysiology and inform targeted therapies and rigorous studies.
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Design
Historical review
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Reminds clinicians of RAAS centrality in COVID-19; leaves open whether modulation improves outcomes in observational data.
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Lessons learned from severe acute respiratory syndrome coronavirus (SARS-CoV) have facilitated a better understanding of the COVID-19 pandemic and efforts to develop targeted therapies. In particular, COVID-19 reminds us of the importance of the renin-angiotensin-aldosterone system (RAAS) in cardiovascular, pulmonary, and kidney physiology. After decades of RAAS research, we can apply this knowledge to better understand COVID-19 pathophysiology and to inform rigorous studies.
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Bhalla et al. (2020) studied this question.
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