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July 16, 2004BMC GenomicsOpen Access

Expression profile of genes regulated by activity of the Na-H exchanger NHE1

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Why the study?

Does decreased intracellular pH induced by impaired NHE1 activity alter gene expression in mammalian fibroblasts?

Population

mammalian fibroblasts

Comparison

decreased intracellular pH induced by impaired… vs normal intracellular pH / normal NHE1 activity

Design

Preclinical

Authors

LPLuanna K. PutneyUniversity of California, San FranciscoDBDiane L. BarberUniversity of California, San Francisco

Discussion

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Implication

Hypothesis-generating for pH effects on fibroblast proliferation genes; leaves open relevance to human cardiovascular disease.

Structured PICO

Does decreased intracellular pH induced by impaired NHE1 activity alter gene expression in mammalian fibroblasts?

P
Population
mammalian fibroblasts
I
Intervention
decreased intracellular pH (pHi) induced by impaired activity of the plasma membrane Na-H exchanger NHE1
C
Comparator
normal intracellular pH / normal NHE1 activity
O
Outcome
global profile of regulated genessurrogate

Decreased intracellular pH via impaired NHE1 activity regulates the expression of genes primarily involved in growth factor signaling, oncogenesis, and cell cycle progression in mammalian fibroblasts.

Cite This Study

Putney et al. (2004) studied this question.

synapsesocial.com/papers/6a6f7aeff44fa9f079dced99https://doi.org/10.1186/1471-2164-5-46
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Also Consider

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  1. 1CHOP-Dependent Stress-Inducible Expression of a Novel Form of Carbonic Anhydrase VI1999 · 147 citations
  2. 2A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.1984 · 556 citations
  3. 3The Changing Face of the Na<sup>+</sup>/H<sup>+</sup> Exchanger, NHE1: Structure, Regulation, and Cellular Actions2002 · 479 citations
  4. 4Stimulation of the Na+/H+ exchanger in human endothelial cells activated by granulocyte- and granulocyte-macrophage-colony-stimulating factor1989 · 65 citations
  5. 5Na–H Exchange Acts Downstream of RhoA to Regulate Integrin-induced Cell Adhesion and Spreading1998 · 202 citations