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Acid‐catalyzed condensation of a series of 3‐oxoalkanoic acid esters with aniline affords the corresponding 2‐alkyl‐4‐quinolones in good yield. Treatment of these compounds with methyl iodide affords 2‐alkyl‐4‐methoxyquinolines and 2‐alkyl‐ N ‐methylquinolones. Three of the compounds are naturally‐occurring alkaloids which are synthesized here for the first time.
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Somanathan et al. (1981) studied this question.
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