Why the study?
Does the APOE ε4 genotype increase the risk for subjective cognitive impairment in elderly persons?
Does the APOE ε4 genotype increase the risk for subjective cognitive impairment in elderly persons?
The APOE ε4 genotype is associated with a higher risk of subjective cognitive impairment in elderly individuals, especially those aged 70 and older.
APOE ε4 carriage was associated with higher subjective cognitive impairment risk after age 70; leaves open whether genotyping informs screening or prevention.
The authors compared the risk for subjective cognitive impairment (SCI) between carriers of the apolipoprotein E ε4 (APOE ε4) allele (cases) and APOE ε4 noncarriers (controls). SCI was assessed by a validated self-reported questionnaire. The authors used multivariable logistic regression analyses to compute odds ratios and 95% confidence intervals adjusted for age, sex, education, and marital status. Data were available on 114 participants (83 women; 47 APOE ε4 carriers; mean age, 69 years). The risk for SCI was significantly higher among cases than controls, particularly for those 70 years of age and older. These findings should be considered preliminary until confirmed by a prospective cohort study.
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Krell‐Roesch et al. (2015) studied this question.
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