September 1, 1994Journal of Clinical InvestigationOpen Access

Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides.

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Population

Mice (SMA, DBA/1J (H-2q), O20/A (H-2pz1), and SJL (H-2s) strains)

Design

Preclinical

Authors

HKHideko KasaharaPediatric / Congenital Cardiology MIMasahiko ItohHokkaido Information University TSTsuyoshi SugiyamaGifu University of Medical Science

Discussion

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Implication

Establishes a new murine myocarditis model; hypothesis-generating for autoimmune dilated cardiomyopathy pathogenesis with no immediate clinical implications.

Structured PICO

Population

Mice (SMA, DBA/1J (H-2q), O20/A (H-2pz1), and SJL (H-2s) strains)

Intervention

Repeated immunization using murine cardiac C-protein with Klebsiella pneumoniae O3 lipopolysaccharide adjuvant, or a fusion protein encoded by part of the C-protein cDNA

Outcome

Induction of autoimmune myocarditis

This study establishes a new murine model of autoimmune myocarditis induced by cardiac C-protein, providing a tool to study the pathogenesis of dilated cardiomyopathy.

Cite This Study

Kasahara et al. (1994) studied this question.

synapsesocial.com/papers/6a6f7cf1660549caf2c407c8 https://doi.org/10.1172/jci117416

Topics

Myocarditis

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Implication

Establishes a new murine myocarditis model; hypothesis-generating for autoimmune dilated cardiomyopathy pathogenesis with no immediate clinical implications.

Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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