July 1, 1966The Journal of Experimental MedicineOpen Access

Crystal-Induced Inflammation in Canine Joints

View Full Paper

Ask AI

Bookmark

Why the study?

Does injection of sodium urate or calcium pyrophosphate crystals induce an acute exudative response in the stifle joints of anesthetized dogs?

Population

Anesthetized dogs

Design

Preclinical

Authors

DMDaniel J. McCartyUniversity of Wisconsin–Stevens Point PPPaulding PhelpsMaine Medical Center JPJacob Pyenson

Discussion

Member takes

Implication

Provides reproducible canine model for crystal arthritis; leaves open translation to human gout.

Structured PICO

Does injection of sodium urate or calcium pyrophosphate crystals induce an acute exudative response in the stifle joints of anesthetized dogs?

Population

Anesthetized dogs

Intervention

Injection of sodium urate or calcium pyrophosphate crystals into the stifle joints

Outcome

Acute exudative response quantified by serial measurements of intra-articular pressure, pH, and leukocyte concentrationsurrogate

Injection of sodium urate or calcium pyrophosphate crystals into canine joints provides a reproducible model of crystal-induced inflammation for studying acute gouty arthritis.

Cite This Study

McCarty et al. (1966) studied this question.

synapsesocial.com/papers/6a6f7d55febe604dd7086629 https://doi.org/10.1084/jem.124.1.99

View Full Paper

Ask AI

Bookmark

Crystal-Induced Inflammation in Canine Joints

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Crystal-Induced Inflammation in Canine Joints

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider