Population
Voltage-gated Na+ channels (preclinical model)
Comparison
Mutation disrupting the interaction between the… vs Wild-type/normal Na+ channels
Design
Preclinical
Authors
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May inform Na channelopathy mechanisms in models; hypothesis-generating for therapies, requires human validation.
The Na+ channel inactivation gate requires a complex interaction between the III-IV loop and the C-T domain, disruption of which delays cellular repolarization and provides a structural basis for channelopathies.
Motoike et al. (2004) studied this question.
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