Why the study?
Some cardiac Na+ channel mutations linked to arrhythmia do not show obvious gain of function using standard patch-clamp techniques, complicating understanding of their disease mechanisms.
Population
Cardiac Na+ channels including SCN5A LQTS mutant I1768V and wild-type channels
Comparison
New experimental approaches under non-equilibrium conditions vs standard patch-clamp techniques under steady-state conditions
Design
Experimental and computational analysis of channel gating
Authors
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No immediate clinical implications for LQT-3; leaves open non-equilibrium gating as hypothesis-generating mechanistic framework.
A combination of computational and experimental analysis of non-equilibrium gating provides a framework to understand the complex mechanisms underlying LQT-3 arrhythmias caused by mutations like SCN5A I1768V.
Clancy et al. (2003) studied this question.
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