Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 27, 1998Circulation Research

Novel LQT-3 Mutation Affects Na+Channel Activity Through Interactions Between α- and β1-Subunits

View Full Paper
Ask AI
Bookmark
Share

Population

Human embryonic kidney cells transiently transfected with wild-type or mutant cDNA alone or in combination…

Comparison

Expression of mutant D1790G SCN5A cDNA vs Expression of wild-type hH1 SCN5A cDNA

Design

Preclinical

Authors

RARui-Hai AnXWX. L. WangBKBatsheva Kerem

Discussion

Loading...

Member takes

Overview

May alter LQT3 mechanism assumptions in models; leaves open whether subunit interactions affect human risk stratification or therapy.

Structured PICO

P
Population
Human embryonic kidney (HEK 293) cells transiently transfected with wild-type (hH1) or mutant (D1790G) cDNA alone or in combination with cDNA encoding the human Na+ channel beta1-subunit (hbeta1)
I
Intervention
Expression of mutant D1790G SCN5A cDNA (with or without beta1-subunit)
C
Comparator
Expression of wild-type hH1 SCN5A cDNA (with or without beta1-subunit)
O
Outcome
Ion channel activity (steady-state inactivation, sustained inward current, biophysical properties) measured using whole-cell patch-clamp proceduressurrogate

The novel LQT-3 mutation D1790G alters sodium channel inactivation through interactions between alpha- and beta1-subunits, rather than causing sustained inward current typical of other LQT-3 mutations.

Cite This Study

An et al. (1998) studied this question.

synapsesocial.com/papers/6a6f7efbfe4101aa97dfcd9bhttps://doi.org/10.1161/01.res.83.2.141
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia1995 · 347 citations
  2. 2The long QT syndrome. Prospective longitudinal study of 328 families.1991 · 970 citations
  3. 3Modulation of Cardiac Na+ Channel Expression in Xenopus Oocytes by β1 Subunits1995 · 140 citations
  4. 4Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin.1995 · 81 citations
  5. 5Correlation between electrical activity and the size of rabbit sino‐atrial node cells.1996 · 24 citations