Why the study?
Does the ACE inhibitor temocapril or the AT1 receptor antagonist CS-866 prevent structural remodeling in rats with L-NAME-induced NO synthesis inhibition?
Population
Rats with coronary vascular and myocardial remodeling induced by long-term inhibition of nitric oxide…
Design
Preclinical
Follow-up
8 weeks
Authors
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AT1 blockade suffices for remodeling prevention in this rat model; leaves open translation to human hypertension.
Does the ACE inhibitor temocapril or the AT1 receptor antagonist CS-866 prevent structural remodeling in rats with L-NAME-induced NO synthesis inhibition?
The beneficial effects of ACE inhibitors on structural remodeling in a rat model of NO synthesis inhibition are primarily mediated by the inhibition of angiotensin II activity via AT1 receptors, rather than bradykinin accumulation.
Takemoto et al. (1997) studied this question.
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