What question did this study set out to answer?

Determine the structural basis for how the anti-idiotypic antibody G6 broadly recognizes antibodies encoded by the IGHV1-69 germline gene.

December 1, 2017Cell ReportsOpen Access

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope

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Authors

YAYuval AvnirHarvard University KPKristina PrachanronarongMount Sinai Health System ZZZhen ZhangFirst Affiliated Hospital of Xiamen University

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Implication

Structural analysis reveals the binding core of anti-idiotypic antibody G6 with target antibody D80, highlighting its broad therapeutic potential in precision medicine.

Key Points

Determine the structural basis for how the anti-idiotypic antibody G6 broadly recognizes antibodies encoded by the IGHV1-69 germline gene.
Determined the co-crystal structure of humanized G6 (hG6.3) complexed with D80, an anti-influenza hemagglutinin stem-directed broadly neutralizing antibody.
Assessed G6 binding breadth against 51p1 IGHV1-69-derived antibodies with differing light chains, CDR-H3 sequences, and antigen specificities.
Resolved the core hG6.3 idiotope to a continuous stretch of CDR-H2 residues spanning positions M53 to N58.
Demonstrated that G6 robustly binds 51p1 IGHV1-69 antibodies across diverse CDR-H3 sequences, light-chain pairings, and antigen targets.

Cite This Study

Avnir et al. (2017) studied this question.

synapsesocial.com/papers/6a6f7f7c6ceb2bbd16dfac6d https://doi.org/10.1016/j.celrep.2017.11.056

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Implication

Structural analysis reveals the binding core of anti-idiotypic antibody G6 with target antibody D80, highlighting its broad therapeutic potential in precision medicine.

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope

Discussion

Member takes

Implication

Key Points

Cite This Study

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope

Discussion

Member takes

Implication

Key Points

Cite This Study

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