What question did this study set out to answer?

To assess bacterial contamination and clinical and serological exposure to Legionellaceae among visitors and staff at a thermal spa following an outbreak of Legionnaires' disease.

February 1, 1989Epidemiology and InfectionOpen Access

Exposure to Legionellaceae at a hot spring spa: a prospective clinical and serological study

View Full Paper

Ask AI

Bookmark

Authors

NBN. BornsteinUniversité Claude Bernard Lyon 1 DMD. MarmetLaboratoire National de Référence MSM SurgotLaboratoire National de Référence

Discussion

Member takes

Implication

Prospective serological study reveals elevated Legionella antibody titers in spa attendees and staff, indicating persistent subclinical bacterial exposure from natural thermal waters.

Key Points

To assess bacterial contamination and clinical and serological exposure to Legionellaceae among visitors and staff at a thermal spa following an outbreak of Legionnaires' disease.
Monitored spring water through repeated microbiological sampling across a 3-month post-cleansing period to isolate and identify Legionella species.
Tested serum samples against 32 Legionella antigens in 689 randomly selected patients, 230 therapists, 134 administrative staff, and a control cohort of 904 blood donors.
Legionellaceae were detected in spring water at concentrations of 10^3 to 10^5 CFU/L, yielding 15 species or serogroups dominated by Legionella pneumophila serogroups 3 and 1.
No clinical cases of Legionnaires' disease occurred, but 11% of therapists and 5% of patients had high antibody titers (>= 256) or seroconverted during follow-up.
Mean antibody titers across all three exposed cohorts were significantly higher than in blood donors against 11 of 32 antigens, with 9 matching water isolates and the highest responses directed against L. pneumophila serogroup 3.

Cite This Study

Bornstein et al. (1989) studied this question.

synapsesocial.com/papers/6a6f7fbca528af2d65c30593 https://doi.org/10.1017/s0950268800029654

View Full Paper

Ask AI

Bookmark

Implication

Prospective serological study reveals elevated Legionella antibody titers in spa attendees and staff, indicating persistent subclinical bacterial exposure from natural thermal waters.

Exposure to Legionellaceae at a hot spring spa: a prospective clinical and serological study

Discussion

Member takes

Implication

Key Points

Cite This Study

Exposure to Legionellaceae at a hot spring spa: a prospective clinical and serological study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider