Why the study?
Do angiotensin-converting enzyme inhibitors reduce microalbuminuria in patients with essential hypertension compared to other agents?
Do angiotensin-converting enzyme inhibitors reduce microalbuminuria in patients with essential hypertension compared to other agents?
Microalbuminuria is prevalent in 10-25% of essential hypertension patients and may be partially corrected by ACE inhibitors.
Microalbuminuria screening may be warranted in essential hypertension; leaves open ACE inhibitor preference pending randomized confirmation.
The prevalence of microalbuminuria in patients with essential hypertension ranges between 10 and 25%. The level of albuminuria is highly correlated with arterial pressure and more closely ambulatory arterial pressure. The interaction between albuminuria and arterial pressure is clearly enhanced by overweight and smoking. The renal mechanisms of microalbuminuria are not well elucidated; an increase in filtration fraction suggestive of intraglomerular hypertension was observed in patients with hyperfiltration. The significance of micro-albuminuria as a marker of cardiovascular risk or hypertensive renal disease needs to be confirmed through long-term follow-up studies. Antihypertensive treatment has variable influence on albuminuria; angiotensin-converting enzyme inhibitors, in contrast to other agents, tend to partially correct this abnormality.
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A Mimran (1997) studied this question.
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