Mammalian macroautophagy at a glance

Autophagy refers to a set of non-specific bulk degradation processes in which cells deliver cytoplasmic substrates for lysosomal degradation. Types of autophagy include macroautophagy, chaperone-mediated autophagy and microautophagy. Chaperone-mediated autophagy is selective for specific cytosolic proteins that contain a pentapeptide motif. This motif is recognised by the chaperone heat shock cognate 70 (Hsc70), which transfers protein substrates to the lysosomal membrane where, through binding to the receptor lysosome-associated membrane