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July 1, 1982Journal of Biological ChemistryOpen Access

Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.

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Authors

DTDaulat R.P. TulsianiVanderbilt UniversityTHThomas M. HarrisThe University of QueenslandOTOscar TousterVanderbilt University

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Tulsiani et al. (1982) studied this question.

synapsesocial.com/papers/6a6f825e26a7f98052dc2a41https://doi.org/10.1016/s0021-9258(18)34274-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Swainsonine prevents the processing of the oligosaccharide chains of influenza virus hemagglutinin.1982 · 125 citations
  2. 2alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.1982 · 295 citations
  3. 3A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescens1979 · 430 citations
  4. 4Purification and properties of α- d -mannosidase from rat epididymis1969 · 60 citations
  5. 5Lipid-saccharide intermediates in glycoprotein biosynthesis. III. Comparison of oligosaccharide-lipids formed by slices from several tissues.1976 · 86 citations