Why the study?
Does rolipram improve symptoms in hospitalized patients with major depressive disorder?
Population
58 hospitalized patients with major depressive disorder
Comparison
Rolipram at three different doses: 3 x 0.25 mg… vs Different doses of rolipram compared against…
Design
RCT, randomized, double-blind
Follow-up
4 weeks
Authors
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Supports targeted rolipram dosing in hospitalized MDD; extends non-monotonic dose-response data for PDE4 inhibitors.
Does rolipram improve symptoms in hospitalized patients with major depressive disorder?
Rolipram demonstrates a reverse U-shaped dose-response curve in major depressive disorder, with 1.5 mg/day (0.5 mg TID) being the most effective dose.
Fleischhacker et al. (2008) studied this question.
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