Why the study?
Is aliskiren safe and well-tolerated in patients requiring antihypertensive therapy?
Population
More than 6400 patients evaluated for safety and tolerability, including black, geriatric, diabetic, obese…
Comparison
Aliskiren (direct renin inhibitor) vs Placebo (in placebo-controlled trials)
Design
Review
Authors
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May inform antihypertensive selection; extends tolerability data but leaves comparative effectiveness open.
Is aliskiren safe and well-tolerated in patients requiring antihypertensive therapy?
Aliskiren is a well-tolerated direct renin inhibitor with an adverse effect profile similar to placebo and a low potential for drug interactions.
Haroonur Rashid (2008) studied this question.
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