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January 12, 2021Journal of Intensive CareOpen Access

Left and right ventricular longitudinal strains are associated with poor outcome in COVID-19: a systematic review and meta-analysis

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Why the study?

It was unclear whether ventricular longitudinal strain can serve as a prognostication tool in patients with COVID-19.

Does lower ventricular longitudinal strain predict poor outcome in patients with COVID-19?

Comparison

Ventricular longitudinal strain measurements in patients with vs without poor outcome

Design

Systematic review and meta-analysis

Authors

AWArief WibowoAirlangga UniversityRPRaymond PranataElectrophysiologyAAAstri AstutiDr. Hasan Sadikin General Hospital

Discussion

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Member takes

Overview

Lower ventricular strain associated with poor COVID-19 outcomes; supports prognostication use but leaves open prospective validation needs.

Structured PICO

Does lower ventricular longitudinal strain predict poor outcome in patients with COVID-19?

P
Population
612 patients with COVID-19 pooled from 7 studies
I
Intervention
Lower left ventricular global longitudinal strain (LV-GLS) and right ventricular longitudinal strain (RV-LS) measured using echocardiography
C
Comparator
Higher LV-GLS and RV-LS
O
Outcome
Poor outcome, defined as a composite of mortality and severe COVID-19composite

Lower left and right ventricular longitudinal strains measured by echocardiography are independently associated with poor clinical outcomes, including mortality, in patients with COVID-19.

Limitations

  • Most included studies were retrospective in design
  • Inadequate data to facilitate diagnostic meta-analysis
  • Cutoff points of LV-GLS and RV-LS were highly polarized
  • Small number of available studies prevented meta-regression analysis
  • Potential confounding by comorbidities such as hypertension and obesity

Cite This Study

Wibowo et al. (2021) studied this question.

synapsesocial.com/papers/6a6f840bfebe604dd7086c7ehttps://doi.org/10.1186/s40560-020-00519-3
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Also Consider

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