[Prognostic risk factors of patients with sepsis and the clinical characteristics of patients with septic myocardial injury].

OBJECTIVE: To analyze the prognostic risk factors of patients with sepsis and the clinical characteristics of patients with septic myocardial injury. METHODS: A retrospective study was conducted. The clinical data of 300 patients with sepsis admitted to emergency department of Zhongshan Hospital of Fudan University from September 2017 to June 2020 were enrolled, including basic information, blood test indicators and auxiliary inspection indicators. The patients were grouped according to myocardial injury and the clinical characteristics of patients with septic myocardial injury were analyzed. According to 28-day prognosis, they were divided into survival group and non-survival group. The differences in various indicators between the two groups were compared, and binary Logistic regression was used to explore independent risk factors for death in patients with sepsis. RESULTS: /L): 10.5 (6.7, 14.6) vs. 8.6 (6.0, 12.0), C-reactive protein (CRP, mg/L): 89.2 (54.8, 128.5) vs. 63.8 (19.3, 105.6), PCT (μg/L): 2.13 (0.31, 11.79) vs. 0.28 (0.10, 1.25), all P < 0.05], and more sinus tachycardia and atrial arrhythmia (41.8% vs. 22.0%, 29.9% vs. 17.7%, both P < 0.05). Logistic regression analysis showed that cTnT increased (OR = 2.115, 95%CI was 1.189-5.459, P < 0.05), sinus tachycardia (OR = 2.557, 95%CI was 1.103-5.929, P < 0.05) and atrial arrhythmia (OR = 2.474, 95%CI was 1.025-5.969, P < 0.05) were independent risk factors for 28-day death in patients with sepsis. CONCLUSIONS: Myocardial injury is an independent risk factor for death in patients with sepsis. PCT elevation, LVEF decreased and sinus tachycardia are main characteristics of patients with septic myocardial injury, which should attract clinical attention.